Steroids, AZT & Malnutrition cause
Mohammed Ali Al-Bayati, Ph.D., DABT, DABVT
Review of the literature for the causes and the
pathogenesis of AIDS worldwide revealed that approximately 90% of AIDS cases
in the USA and Europe are observed in homosexual men and drug users.
The regular uses of alcohol, heroin, cocaine, amphetamines, and alkyl
nitrite cause chronic health problems in the nervous system, respiratory
system, cardiovascular system, kidneys and other tissues in these individuals.
The majority of these health problems are usually diagnosed currently as
idiopathic, and treated with high doses of glucocorticoids and/or cytotoxic
drugs. In addition, some homosexual men are usually heavy users of illicit
drugs, alcohol, and oral and rectal glucocorticoids ( Fauci et al.,
1998; Al-Bayati, 1999).
treatment of a patient with prednisone at 60 mg per day for about three months
can actually cause AIDS as described above. This treatment and doses are often
given to patients suffering from lung fibrosis, thrombocytopenia, or other
chemically induced chronic illnesses.
The reversal of CD4+
T-cells depletion in the peripheral blood was reported in HIV+
homosexual men after the termination of their treatment with glucocorticoids.
The medical evidence shows that AIDS is probably caused by the use of
illicit drugs, therapeutic use of corticosteroids, and malnutrition.
Differential diagnosis indicated that HIV is not involved.
thousands of cases infected with the HIV and they did not show any symptoms
for more than 10 years (Fauci, et al., 1998; Al-Bayati,
Causes and pathogenesis
of AIDS in drug users and homosexuals
The appearance of AIDS in
the USA and Europe in drug users and homosexuals in the late 1970ís and early
1980ís coincided with the synergistic actions of several events. Briefly,
these include the spread of illicit drug use, especially smoking crack cocaine
and heroin in 1970ís, the approval of aerosols containing
glucocorticoids by the U.S. FDA in 1976, the wide use of the
glucocorticoid inhalers to treat chronic respiratory illnesses resulting from
inhaling cocaine and heroin, the wide use of alkyl nitrites by
homosexuals to facilitate anal sex in 1970ís, and the wide use of
corticosteroids to treat chronic gastrointestinal tract illness in
homosexuals. Furthermore, the approval of anti-retroviral drugs (AZT and protease inhibitors) and
the steroids by the U.S. FDA to treat patients with AIDS and asymptomatic
patients infected with HIV has exacerbated the problem (Al-Bayati,
The HIV hypothesis states that HIV causes AIDS by killing the
CD4+ T-cells directly or indirectly (Fauci, et al., 1998). It appears
that there is no scientific evidence to show that HIV can kill infected T4
cells (CD4+ T-cells) in vitro or in vivo. In addition,
the abnormalities in the immune system of patients with AIDS are not
restricted to the reduction of T4 cells as predicted by the HIV hypothesis.
Hoxie et al. (1985) observed no evidence of death in T-cells infected
with HIV in tissue culture. These cells continued to produce virus particles
for more than four months after inoculation with the virus. Many reports
describe the changes in the lymph nodes of patients infected with HIV and
these changes range from extensive cellular hyperplasia (excessive production)
of T and B lymphocytes and the supporting stroma to severe atrophy of the
glands. Changes in the lymph nodes of 505 HIV- infected patients who
were asymptomatic or had AIDS demonstrate three distinct stages. These are
hyperplasia (245 patients), atrophy (117 patients), and mixed stage (172
patients) (Al-Bayati, 1999). The occurrence of hyperplasia in the
infected lymph nodes contradicts the HIV hypothesis which states that HIV
destroys infected T-cells (Gallo, 1987; Fauci et al., 1998).
The changes in the lymph nodes described above are not unique to
HIV-infected individuals, but have also been found in
HIV-negative patients in risk groups. The lymph nodes of 215
HIV-negative homosexual men who were drug users showed hyperplasia
and atrophy, and lymph nodes of 15 men showed Kaposiís sarcoma and lymphoma.
These changes are AIDS-indicator diseases based on the CDCís
criteria, yet the subjects were HIV-negative
Duesberg, (1992) stated that HIV infects on
the average only 0.1% (1 out of 500 to 3000) of T-cells in AIDS
patients, and at least 3% of all T-cells are regenerated during the two
days it takes a retrovirus to infect a cell. HIV could never kill enough
T-cells to cause immunodeficiency. Thus, even if HIV killed every
infected T-cell, it could deplete T-cells only at 1/30 of their
normal rate of regeneration, not considering activated regeneration.
The study by me and my colleagues (Al-Bayati et al. 1990) also
showed that the rate of regeneration in the damaged thymus and lymphoid tissue
of mice treated with a lymphotoxic agent (vanadate) was very rapid.
In addition to illicit drug and alcohol abuse, some homosexuals are
also heavy users of alkyl nitrites that relax the anal muscle and facilitate
anal sex. It has been stated that the use of alkyl nitrites permeated the gay
life by 1977 (Al-Bayati, 1999).
usually suffer from acute and chronic rectal and gastrointestinal diseases
that dictate the heavy therapeutic use of rectal steroids. Among 7 selected
studies that included 736 patients who were infected with HIV and/or had AIDS,
97% were homosexual or bisexual men. They show clearly that homosexual
men suffer from extensive rectal and gastrointestinal problems that result in
chronic use of therapeutic rectal steroids (Al-Bayati, 1999).
Review of the
medical literature revealed that the short and the long term use of
glucocorticoids at therapeutic doses, resulted in a variety of effects on the
immune system that range from a transient reduction in T-cells count in
peripheral blood to the development of full blown AIDS. Since the harmful
effect of corticosteroids is broad, it is not surprising that many types of
infections seem to occur more often in patients treated with corticosteroids.
In addition, Kaposiís sarcoma (KS) can develop, independently of HIV,
in patients chronically treated with glucocorticoids. Many cases, which
developed KS following treatment with glucocorticoids, had reversal of their
lesions after the termination of the treatment (Al-Bayati, 1999).
The high prevalence of adrenal insufficiency among AIDS patients
provides very strong evidence that AIDS in these patients is caused by the use
of corticosteroids. The most common abnormality seen in HIV-infected
individuals is hyponatremia, which is found in up to 30 percent of patients.
Scientists have also stated that the presence of a low sodium level, combined
with a high serum potassium level, in a patient should alert one to the
possibility of adrenal insufficiency and adrenocortical insufficiency as seen
following prolonged administration of excess glucocorticoids.
Furthermore, as stated above, that the CD4+ T-cells depletion
in the peripheral blood of HIV-positive homosexual men was reversed
after the termination of their treatment with glucocorticoids, and at least
77% of 2349 patients who participated in the four major AZT clinical
trials (1987-1992) were HIV-negative prior to their treatment
with AZT. These studies demonstrate clearly that HIV is not the cause of AIDS
Causes and pathogenesis of AIDS
and children in USA and
As of January 1, 1997, the number of infants and children in
USA diagnosed with AIDS was 6891, and ninety percent of these cases had
mothers who were drug users (Fauci et al., 1998; Al-Bayati, 1999).
The results of nine large studies surveying the prevalence of drug use in
relation to the outcome of pregnancy in the USA showed that up to 15% of
pregnant women used cocaine during pregnancy based on a positive urine test.
Infants and children with AIDS are dying from opportunistic infections
as a result of malnutrition and the excessive use of therapeutic steroids to
treat the wide range of illnesses in these children.
Causes and pathogenesis of AIDS
The medical evidence suggests that AIDS in hemophiliac
patients is probably caused by the treatment with immunosuppressive agents
(cyclophosphamide and glucocorticoids) which have been used to prevent the
development of antibodies to factors VIII and XI in patients with hemophilia
(Al-Bayati, 1999). Patients with severe hemophilia have serious chronic
joint problems resulting from bleeding inside the joints. That is also treated
with glucocorticoids (Al-Bayati, 1999). AIDS has been reported in
HIV-negative and HIV-positive hemophiliac patients.
Causes and pathogenesis of AIDS
in organ transplant
and / or blood transfusion
As of January 1, 1997, the number of patients who
received blood transfusions, blood components or tissues, and then
subsequently developed AIDS in USA is 7888 (Al-Bayati, 1999).
Furthermore, glucocorticoids and other immuno-suppressive agents are
also used to prevent tissue rejection in organ transplant patients.
Blood transfusion patients and people with organ transplants develop
AIDS after being treated with corticosteroids, and the list of opportunistic
diseases described in these groups are similar to those described in people
with AIDS (Fauci, et al., 1998).
Causes and pathogenesis of AIDS
There is extensive literature describing the impact of
malnutrition on the function and the structure of the immune system in people
in Africa (Al-Bayati, 1999). This information clearly demonstrates that
AIDS in Africa is more likely to be caused by starvation than by HIV. The
functions of the immune system, especially the cellular immunity, are impaired
in malnutrition cases. The severity of the impairment is dependent on the
degree of malnutrition in both humans and animals.
Atrophy in the
lymphoid organs in malnourished people is caused by increased levels of
cortisol as well as by protein and vitamin deficiency. The reduction in the
thymus and the lymphoid tissue size and the reduction in the function of the
immune system of malnourished children and animals were reversed after proper
feeding. For example, the size of the thymus increased from 20% of normal in a
malnourished child to 107% of normal following 9 weeks of proper feeding. The
reversal in the reduction of CD4+ T-cell count in HIV+ pregnant
women following proper feeding was also reported by Fawzi et al., (1998).
Briefly, the influence of diet on T-cell counts in peripheral
blood was studied in 1075 HIV-infected pregnant women who had poor
nutritional status. The CD4+ T-cell counts of the women who received
multivitamins increased from 424/ĶL to 596/ĶL during six months of proper
Furthermore, the large study of Fawzi et al.,
1998, clearly demonstrated that HIV is not implicated, and the impairment of
the immune system in a mother (HIV-positive) who suffers from
malnutrition can be reversed by feeding the mother proper nutrition. This
treatment also improved the outcome of pregnancy.
The logical steps that should be taken to prevent
AIDS and to cure people with AIDS are:
the causes of AIDS by educating the public about the toxic effects of the
illicit drugs and alcohol.
2) Limit the use of
glucocorticoids in the treatment of chronic conditions and in the treatment of
people with AIDS.
3) Monitor the levels of CD4+ T-cells
and CD8+ T-cells in the blood of patients who are receiving medium or
high therapeutic doses of glucocorticoids for
4) Discontinue the treatment of
patients having AIDS and asymptomatic patients with AZT and protease
inhibitors immediately. These are very toxic medications.
Provide proper clinical support and nutrition to patients with AIDS based on
their medical needs. Prior to the development of full-blown AIDS in
drug users and homosexuals, the damage is caused by the use of drugs.
6) Alpha lipoic acid is a powerful antioxidant that has been used to
prevent injury caused by chemicals in vivo and in vitro and
injuries in diabetic patients for the last two decades (Al-Bayati,
1999). It has been used in Europe to reverse peripheral neuropathy in diabetic
patients and has been shown to be effective and safe in several clinical
trials. This drug is very effective in preventing and reversing injuries
resulting from metabolic changes and/or exposure to chemicals that induce
lipid peroxidation. This medication should be given to people with AIDS to
boost the immune system and to heal tissue injury (Al-Bayati, 1999).
Al-Bayati, M.A. (1999). Get All The Facts: HIV does not Cause AIDS.
International, Dixon, California (http://www.toxi-health.com
Culbertson, R.M.; Schreider, J.P.; Rosenblatt, L.S.; and Raabe, O.G.
(1992). The Lymphotoxic Action of Vanadate. Journal of Environmental
Toxicology and Oncology, 11(2):19-27.
Duesberg, P.H. (1992). AIDS
Acquired by drug consumption and other noncontagious Risk Factors. Pharmac.
Ther. Vol.55, 201-277.
Fauci A.S.; Braunwald, E.;
Isslbacher, K.J.; et al. Harrisonís. Principles of Internal
Medicine. (McGraw-Hill Companies, Inc. New York USA, ed. 14,
Fawzi, W.W.; Msamanga, G.I.; Spiegelman, D.; et
al. (1998). Randomized trial effects of vitamin supplements on pregnancy
outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet
Gallo, R.C. (1987). The AIDS Virus. Scientific America.
Hoxie, J.A.; Haggarty, B.S.; Rackowski, J.L.;
et al. (1985). Persistent Noncytopathic Infection of Normal Human T
lymphocytes with AIDS-Associated Retrovirus. Science 229(4720):1400.
Dr Mohammed Ali Al-Bayati
Toxicologist and Pathologist
150 Bloom Dr.
Dixon, CA 95620
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